Mixture toxicity workshop

• Intro and scope
• Intended audience
• Organising committee
• Contact
• Registration fee
• Accommodation
• Topics
• Speakers
• Sponsors
• Preliminary Programme
• Venue

Intro and scope

Contaminants never occur in isolation yet legislation is still largely based on effects of single compounds. In addition, more and more data are becoming available that suggest that compounds can exert effects in organisms when present in mixtures in concentration ranges at which the single contaminants do not induce effects. The examination of combined exposures, which corresponds much more realistically to exposure conditions in the environment than the analysis of single substances, entails major methodological difficulties in the experimentation and evaluation procedure. This workshop intends to introduce you to some of the approaches and methodologies used in studying and predicting mixture toxicity effects.

This workshop aims to provide:

• A description of the principal concepts of concentration addition and independent action for predicting mixture toxicity, their range of applicability and their limitations.
• An overview of the available designs for a particular mixture toxicity related research question.
• An overview of ways to address deviations from the existing reference models
• An in-depth knowledge on the concept of the Dynamic-Energy-Budget (DEB) theory, and the effects of toxicants and mixture exposure within this theory.
• Practical statistical approaches to be able to tackle linear and generalised linear modelling

The workshop will be a mixture of theoretical presentations and individual practical calculation sessions.